A ballpark range for a 6" round typical supply run is around 100 CFM for a properly designed duct system at full blower speed. It will be less when running at a lower speed, cooling is generally a higher speed than heating. It will also be less on modulating furnaces running on low fire, or low speed continuous circulation. That's the variables for a properly designed duct system, and that's based on 100 equivalent feet of duct. Residential duct should be designed per ACCA manual D.
More length reduces airflow. Elbows reduce airflow, and the type of elbows used in rectangular duct can make a big difference, especially if you have more than one within a short distance. A long straight supply trunk line is better than a shorter trunk with lots of bends. If the main trunk line size isn't reduced as individual runs come off it, or if it's oversized, you will lose static pressure and therefore airflow at the farther runs, particularly for longer trunk lines. Not enough return air can also be a problem, but you really can't oversize your return. Flex duct reduces airflow even when installed right, which it usually isn't. It can be a real killer to airflow if not done right.