Amounts of hazardous materials can be increased more ways than separating with fire rated construction. The use of listed hazardous material cabinets give significant increases to amounts of hazardous materials and would be much cheaper than fire sprinklers. The occupancy designation dictates the number of control areas a space can have and limits the types and quantities of hazardous material per area within that occupancy, before it is kicked into an H occupancy.
It sounded like in the OP the interest was in limiting the amount of fire area to avoid sprinklers?? Separate buildings, fire walls, fire barriers and horizontal assemblies are the only ways to create separate fire areas. Non-separated mixed use buildings are all one building regardless if multiple levels and in your cases sounds like would need to be sprinkled. A separated mixed use building could be separate fire areas, but remember to go back and read the constraints of mixed use separated vs. non-separated.
BB has been pointing you in the right direction here.
ZIG